Haptoglobin, an inflammation-inducible plasma protein
نویسندگان
چکیده
منابع مشابه
Haptoglobin, inflammation and disease.
Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein's function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HIV, tuberculosis) a...
متن کاملHaptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.
Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense. Despite the assumption hitherto that Hpr does not bind to hemoglobin, the present study revealed that recombinant Hpr binds hemoglobin as efficiently as haptoglobin (Hp). However, i...
متن کاملLow plasma haptoglobin in march haemoglobinuria.
A student had haemoglobin in the urine after running but not after cycling. The haemoglobinuria was related to the hardness of the surface on which he ran and to his running style. The concentration of haptoglobin in his plasma was less than normal. This was most pronounced after he had been running, when haptoglobin had combined with free haemoglobin, but the concentration was also low when th...
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Binge drinking has been associated with cerebral dysfunction. Ethanol induced microglial activation initiates an inflammatory process that causes upregulation of proinflammatory cytokines which in turn creates neuronal inflammation and damage. However, the molecular mechanism is not fully understood. We postulate that cold-inducible RNA-binding protein (CIRP), a novel proinflammatory molecule, ...
متن کاملHaptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm.
OBJECTIVE Inflammation is associated with the disruption of the aortic media and appears to play a fundamental role in the progression and development of abdominal aortic aneurysm (AAA). Haptoglobin (Hp) is a genetically determined acute phase protein, the synthesis of which is increased during inflammation. This study was designed to investigate both phenotype and plasma levels of Hp in patien...
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ژورنال
عنوان ژورنال: Redox Report
سال: 2001
ISSN: 1351-0002,1743-2928
DOI: 10.1179/135100001101536580